Copper(II) 2-(N-Tosylamino)benzaldehyde Benzoylhydrazone Complexes: Synthesis, Structures, Properties, and Biological Activity

A number of new copper(II) complexes of 2-( N -tosylamino)benzaldehyde benzoylhydrazone (H 2 L) CuLL n ( n = 1–6) with heterocyclic donor ligands (L 1 = 1-propyl-2-aminobenzimidazole, L 2 = 1‑hexyl-2-aminobenzimidazole, L 3 = 1-octyl-2-aminobenzimidazole, L 4 = 2,2'-bipyridine, L 5 = 1,10-phenanthroline, and L 6 = 2-aminopyridine) is synthesized. The structures and compositions of the synthesized compounds are determined by elemental analysis, 1 Н NMR spectroscopy, IR spectroscopy, and magnetochemistry. The molecular structures of complexes CuLL 1,2,4−6 are determined by XRD (CIF files CCDC nos. 2341480 (CuLL 1 ), 2341468 (CuLL 2 ), 2341478 (CuLL 4 ), 2341477 (CuLL 5 ), and 2341479 (CuLL 6 )). The biological activity of the complexes is studied. The adducts with L 1 , L 2 , and L 6 exhibit a significantly higher anti-protist activity than chloroquine used as the reference compound.