Two New Compounds from Arctium lappa Roots

Two New Compounds from Arctium lappa Roots

A new caffeoylquinic acid, 1, 5-di-O-caffeoyl-3-O-(1-O-methoxy-2-O-caffeoyl-4-maloyl)-quinic acid (1), and a new 5-hydroxymethylfurfural dimer, 5-(((2-methoxymethyl) furan-5-methanol) methyl) furan-2-carbaldehyde (2), were discovered from Arctium lappa roots. A comprehensive HRMS, UV, IR, 1D and 2D...

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Veröffentlicht in:Records of natural products 2024-09, Vol.18 (5), p.490-498
Hauptverfasser: Dai, Liping, Yang, Qingyu, Chi, Jun, Zhang, Weijin, Zhang, Lingxia, Wang, Zhimin
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Cell culture
Chinese medicine
Chromatography
Collaboration
R&D
Research & development
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Zusammenfassung:A new caffeoylquinic acid, 1, 5-di-O-caffeoyl-3-O-(1-O-methoxy-2-O-caffeoyl-4-maloyl)-quinic acid (1), and a new 5-hydroxymethylfurfural dimer, 5-(((2-methoxymethyl) furan-5-methanol) methyl) furan-2-carbaldehyde (2), were discovered from Arctium lappa roots. A comprehensive HRMS, UV, IR, 1D and 2D NMR techniques were used for structural identification. These two compounds had Nitric Oxide (NO) inhibitory activity in lipopolysaccharide (LPS)-stimulated RAW 264.7 inflammatory cell in a dose-dependent manner.
ISSN:1307-6167
1307-6167
DOI:10.25135/rnp.474.2404.3187