Abstract 245: Dose‐dependent relationship between periodontal disease and ischemic stroke

IntroductionThe link between periodontal disease and cerebrovascular disease was reported in various studies, with several mechanistic underpinnings. To determine the predictive value of periodontal disease for cerebrovascular diseases, we aimed to investigate the quantitative association between various degrees of periodontal disease and subtypes of cerebrovascular disease.MethodsUsing Meta‐analyses Of Observational Studies in Epidemiology and PRISMA guidelines, we searched 6 databases through May 2024 for cohort and case‐control studies evaluating the relationship between periodontal disease and ischemic or hemorrhagic stroke. Studies were included if they reported risk ratios (RRs) and 95% confidence intervals or raw patient‐level data (that were computed into RRs). Unadjusted and vascular risk‐factor adjusted ORs were pooled into meta‐analysis using DerSimonian Laird random effects model. Study quality, publication and dissemination biases were assessed and integrated in the analyses (RevMan software).Results12 prospective studies encompassing 31, 324 patients were eligible for the qualitative and quantitative syntheses. After vascular risk‐factor adjustment, any degree of periodontitis was associated with an increased risk of ischemic stroke (RR, 2.24, 95% CI [1.67‐2.98], p