An Attractive and Efficient Method for Preparation of Propargyl Amines: Presentation of a Novel Magnetically Reusable Manganese Nanocatalyst for C-N Bond Formation

In this research project, we first synthesized the magnetic manganese nanocatalyst by immobilizing the MnCl 2 on the surface of magnetic Fe 3 O 4 nanoparticles modified with catechol and piperazine/phenanthroline ligand [Fe 3 O 4 @Catechol/PZ-Phen-MnCl 2 ], then we evaluated its catalytic performance in the synthesis of propargyl amines through the A 3 and KA 2 -coupling three-component reactions aromatic aldehydes or ketones, with alkynes, and amines. FT-IR, SEM, TEM, EDX, XRD, TGA, VSM, ICP-OES and elemental mapping analyzes confirmed the successful synthesis of Fe 3 O 4 @Catechol/PZ-Phen-MnCl 2 nanocatalyst. The results of the coupling reactions confirmed that the Fe 3 O 4 @Catechol/PZ-Phen-MnCl 2 nanocomposite is a very efficient catalyst for the preparation of various derivatives of propargyl amines. This method has significant features compared to the previous methods, which can be mentioned as follows: synthesis of products with very high efficiency, carrying out the reaction under mild conditions and compatible with the environment, using green and recyclable catalyst, can being applicable to a wide range of substrates and providing NMR analysis for all propargyl amine products. Graphical Abstract