Anti-N-Methyl-D-Aspartate Receptor Encephalitis Following Fourth Dose of COVID-19 Vaccination: A Case Report

Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis has been reported after severe acute respiratory disease coronavirus 2 (SARS-CoV-2) vaccination rarely. We report the second known case of anti-NMDAR encephalitis after receiving fourth dose of SARS-CoV-2 vaccine in a middle-aged male presenting with stroke-like symptoms, highlighting a rare potential neuroinflammatory complication of vaccination against SARS-CoV-2 that is currently being distributed worldwide. Despite the occurrence of such rare adverse events, the benefits of COVID-19 vaccination outweigh concerns over neurologic complications.