Reaction of 5-Hydroxypyrazolidine with Thiol-Containing Hydrazides as a Route to Biologically Active Ligands for Gold Glyconanoparticles

Reaction of 5-Hydroxypyrazolidine with Thiol-Containing Hydrazides as a Route to Biologically Active Ligands for Gold Glyconanoparticles

The reaction of (3S)-1-acetyl- 5-hydroxy-2-phenyl-3-methylpyrazolidine with 6-mercaptohexanoic and 11-mercaptoundecanoic acid hydrazides gives in 60–65% yields (3 S )-1-acetyl-5-[(ω -mercaptoacyl)hydrazino]-2-phenyl-3-methylpyrazolidines, promising coligands for preparing gold glyconanoparticles for...

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Veröffentlicht in:Russian journal of organic chemistry 2024-07, Vol.60 (7), p.1348-1350
Hauptverfasser: Ershov, A. Yu, Martynenkov, A. A., Lagoda, I. V., Batyrenko, A. A.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Gold
Hydrazides
Organic Chemistry
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Zusammenfassung:The reaction of (3S)-1-acetyl- 5-hydroxy-2-phenyl-3-methylpyrazolidine with 6-mercaptohexanoic and 11-mercaptoundecanoic acid hydrazides gives in 60–65% yields (3 S )-1-acetyl-5-[(ω -mercaptoacyl)hydrazino]-2-phenyl-3-methylpyrazolidines, promising coligands for preparing gold glyconanoparticles for the biomedical purpose.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428024070273