syn -1,2-Diaminobenzocyclobutenes from [2+2] cycloaddition of 2-imidazolones with arynes

syn -1,2-Diaminobenzocyclobutenes from [2+2] cycloaddition of 2-imidazolones with arynes

Formal [2+2] cycloaddition of arynes with 2-imidazolones affords -1,2-diaminobenzocyclobutenes. The transformation can also be conducted as a one-pot, three-stage process direct from simple propargyl amines and isocyanates to afford the new stereochemically defined benzocyclobutene frameworks.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2024-10, Vol.60 (83), p.11928-11931
Hauptverfasser: Ur Rehman Shah, Haseeb, Li, Qi, Jones, Christopher R
Format: Artikel
Sprache:eng
Schlagworte:
Amines
Cycloaddition
Heterocyclic compounds
Isocyanates
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Zusammenfassung:Formal [2+2] cycloaddition of arynes with 2-imidazolones affords -1,2-diaminobenzocyclobutenes. The transformation can also be conducted as a one-pot, three-stage process direct from simple propargyl amines and isocyanates to afford the new stereochemically defined benzocyclobutene frameworks.
ISSN:1359-7345
1364-548X
DOI:10.1039/d4cc04023f