Frontispiece: Discovery, Total Synthesis, and Anti‐Inflammatory Evaluation of Naturally Occurring Naphthopyrone‐Macrolide Hybrids as Potent NLRP3 Inflammasome Inhibitors

Frontispiece: Discovery, Total Synthesis, and Anti‐Inflammatory Evaluation of Naturally Occurring Naphthopyrone‐Macrolide Hybrids as Potent NLRP3 Inflammasome Inhibitors

Natural Products. The NLRP3 inflammasome plays a crucial role in regulating the innate immune system and inflammatory signaling. In their Research Article (e202405860), Dehai Li and co‐workers report that a naphthopyrone‐macrolide hybrid derived from Antarctic fungus serves as a potent NLRP3 inflamm...

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Veröffentlicht in:Angewandte Chemie International Edition 2024-10, Vol.63 (43), p.n/a
Hauptverfasser: Sun, Chunxiao, Jiang, Yuqi, Li, Changlong, Sun, Simin, Lin, Jiaqi, Wang, Wenxue, Zhou, Luning, Li, Liping, Shah, Mudassir, Che, Qian, Zhang, Guojian, Wang, De, Zhu, Tianjiao, Li, Dehai
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Hybrids
Immune system
Inflammasomes
Inflammation
Innate immunity
Natural products
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Zusammenfassung:Natural Products. The NLRP3 inflammasome plays a crucial role in regulating the innate immune system and inflammatory signaling. In their Research Article (e202405860), Dehai Li and co‐workers report that a naphthopyrone‐macrolide hybrid derived from Antarctic fungus serves as a potent NLRP3 inflammasome inhibitor.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202484361