A New Antibacterial Indole Alkaloid from Cigar Tobacco and Its Potential Application in Antiseptic Cigarette Tipping Paper

A new indole alkaloid, cigarindole A ( 1 ), together with five known indole alkaloids ( 2–6 ) were isolated from cigar tobacco. Their structures were elucidated using spectroscopic methods, including extensive 1D and 2D NMR techniques. Interestingly, compound 1 exhibited high antibacterial activity with bacteriostatic diameter within the range 20.6–26.7 mm against five pathogenic strains (Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae , Bacillus subtilis , and Proteus spp). Compounds 2–6 exhibited obvious antibacterial activity with bacteriostatic diameter within the range 11.9–21.8 mm. In addition, compound 1 also the potential value for use as an antiseptic agent for cigarette tipping paper.