Synthesis and Phosphorylation of 5-Arylidenthiobarbiturates

Synthesis and Phosphorylation of 5-Arylidenthiobarbiturates

A series of 5-arylidene-2-thiobarbiturates was synthesized by Knoevenagel condensation from thiobarbituric acid under mild conditions; the use of water as a solvent allowed obtaining the target products in yields up to 78%. The addition reaction of dimethyl phosphite to 5-arylidene-2-thiobarbiturate...

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Veröffentlicht in:Russian journal of general chemistry 2024-08, Vol.94 (8), p.1955-1961
Hauptverfasser: Epifantseva, V. E., Skryl’kova, A. S., Bespalov, D. S., Chekalov, A. P., Egorov, D. M.
Format: Artikel
Sprache:eng
Schlagworte:
Cesium fluorides
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Condensates
Phosphorylation
Thiobarbituric acid
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Zusammenfassung:A series of 5-arylidene-2-thiobarbiturates was synthesized by Knoevenagel condensation from thiobarbituric acid under mild conditions; the use of water as a solvent allowed obtaining the target products in yields up to 78%. The addition reaction of dimethyl phosphite to 5-arylidene-2-thiobarbiturates was studied. The optimal conditions for this reaction were selected, and the high efficiency of cesium fluoride as catalyst was shown.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363224080073