Heart Conditioning as a Healthy Strategy in Adjunctive Treatment of Cardiovascular Disease: Clinical Trials

Purpose of Review This review highlights the clinical significance and ongoing clinical trials of heart conditioning as a healthy strategy, for reversing disease and aging. This approach is compatible with the heterochronic parabiotic model, as evidenced by reverse remodeling. Recent Findings Over the past 38 years, research has shown that heart conditioning can enhance cardiovascular functions, as well as prevent and treat various cardiovascular and cerebrovascular diseases. Chronic heart conditioning as a healthy strategy leads to cardiac reverse remodeling, which may contribute to the reversal of cardiac enlargement and heart failure suggesting the reversion of aging and age-related diseases. Summary Heart conditioning as a healthy strategy may lead to the reversion of disease and aging, serving as a possible adjunctive treatment for cardiovascular diseases.