1486-P: Role of HLA Class I Gene Alleles and Haplotypes in Type 1 Diabetes in Kuwaiti Children
Introduction & Objective: HLA class I genes have a role in influencing immune response and self-tolerance as they bind and present antigens to T cells. Allelic variations of these genes are associated with multifactorial autoimmune conditions including type 1 diabetes (T1D) and show variability...
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Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2024-06, Vol.73, p.1 |
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Sprache: | eng |
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Zusammenfassung: | Introduction & Objective: HLA class I genes have a role in influencing immune response and self-tolerance as they bind and present antigens to T cells. Allelic variations of these genes are associated with multifactorial autoimmune conditions including type 1 diabetes (T1D) and show variability across different ethnic groups and populations. Additionally, the amino acid variations of these genes may affect the binding and immunogenicity of insulin peptide. Methods: We performed an association study of classical HLA class I genes between Kuwaiti T1D children (95 individuals) and adult controls (150 individuals) groups using Next-generation sequencing dataset. Results: Significant associations were identified for alleles at HLA-A and HLA-C genes, including A*02:01 and C*07:01 were both conferred high risk for T1D. The A*24:02~B* 08:01~C*07:02 haplotype was significantly associated with the risk of developing T1D. Furthermore, we identified significant 33 amino acid positions at HLA-B and HLA-C genes that were both predisposing and protective against T1D. Conclusion: Our results suggest that HLA class I genes and their allelic and amino acid variations play a role in modulating the risk of T1D and may have implications for disease risk management and genetic counseling in the Kuwaiti population. |
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ISSN: | 0012-1797 1939-327X |
DOI: | 10.2337/db24-1486-P |