945-P: Safety and Glycemic Outcomes of Adults with Type 2 Diabetes (T2D) in a MiniMed Advanced Hybrid Closed-Loop (AHCL) System Trial

Introduction: In people with T2D (PwT2D) whose glycemic control with non-insulin glucose-lowering drugs (GLDs) is not at goal, progression to insulin therapy can be delayed or dose titration infrequent, which may result in a higher likelihood of complications.1 Small feasibility studies have, recently, demonstrated safe and effective automated insulin delivery (AID) use in PwT2D.2,3 Herein, we report the preliminary safety and glycemic outcomes of a large T2D cohort using MiniMed™ AHCL. Methods: A 13-site, single-arm, study had 95 PwT2D (mean±SD age of 60.3±10.8 years and 18.6±8.6 years T2D duration) who underwent a run-in period (~21 days) of open-loop or HCL therapy followed by a study period (~90 days) of AHCL therapy. Insulin-using participants on ≥1 non-insulin GLD at baseline included MDI (N=41/58); CSII or SAP (N=20/30); and HCL (N=6/7). Severe hypoglycemia (SH), diabetic ketoacidosis (DKA), metrics of glycemic control and insulin delivery were assessed. Results: There were no episodes of SH or DKA during the run-in or study period. A1C, mean SG and TAR were significantly reduced, with AHCL use (Table). TITR, TIR and TDD were significantly increased, with no significant change in weight. Conclusion: These findings show that MiniMed™ AHCL is safe and can significantly improve T2D dysglycemia. Future analyses will assess baseline factors that predict better T2D glycemic control.