1193-P: Patterns of Autoimmunity in Youth with New-Onset Diabetes Mellitus during the COVID Era

Introduction: The incidence of diabetes mellitus increased globally during the COVID pandemic with changes in autoimmunity patterns reported in Europe. We sought to evaluate these patterns in our US-based patient population. Methods: Retrospective chart review of patients 1-21 years of age diagnosed with type 1 diabetes at our institution. Patients diagnosed between 1.2017-2.2020 were categorized as pre-pandemic and those diagnosed between 3.2020-12.2022 as pandemic. Chi-square analysis was used to evaluate the difference in autoantibody patterns between these periods. Results: During the pandemic, 385 patients were diagnosed with T1DM compared with 377 patients in the pre-pandemic period. Compared to the pre-pandemic period, the proportion of patients with positive for IA2A during the pandemic decreased from 72.5% to 63.9% (p