1564-P: Hepatic Lipid Content Associates with Fasting and Prandial Glucagon Secretion in Recent-Onset Type 2 Diabetes

1564-P: Hepatic Lipid Content Associates with Fasting and Prandial Glucagon Secretion in Recent-Onset Type 2 Diabetes

Hyperglycemia in type 2 diabetes (T2D) associates with higher glucagon secretion, which may be further promoted in the presence of metabolic dysfunction-associated steatotic liver disease (MASLD). Thus, we compared fasting and prandial glucagonemia in people with and without recent-onset T2D and MAS...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2024-06, Vol.73, p.1
Hauptverfasser: Huttasch, Maximilian, Kahl, Sabine, Mori, Tim, Heilmann, Geronimo, Trinks, Nina, Schön, Martin, Giannakogeorgou, Anna, Trenkamp, Sandra, Kupriyanova, Yuliya, Schrauwen-Hinderling, Vera, Albrechtsen, Nicolai J Wewer, Burkart, Volker, Wagner, Robert, Roden, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Diabetes
Diabetes mellitus (non-insulin dependent)
Fasting
Glucagon
Glucose
Glucose tolerance
Hyperglycemia
Liver diseases
Magnetic resonance spectroscopy
Peptides
Secretion
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Zusammenfassung:Hyperglycemia in type 2 diabetes (T2D) associates with higher glucagon secretion, which may be further promoted in the presence of metabolic dysfunction-associated steatotic liver disease (MASLD). Thus, we compared fasting and prandial glucagonemia in people with and without recent-onset T2D and MASLD. Participants of the German Diabetes Study (GDS), with T2D (n=50; known duration 0.05), whereas T2D featured lower insulin sensitivity (M-value: 7.2±2.7 vs. 9.8±3.1 mg/kg*min, p
ISSN:0012-1797
1939-327X
DOI:10.2337/db24-1564-P