1180-P: Blood Pressure and Hormonal Factors in Adolescent with Type 1 Diabetes
Introduction & Objective: Hypertension is common in type 1 diabetes (T1D). Renin-angiotensin aldosterone system (RAAS) and calcium-phosphate metabolism modulate blood pressure (BP). This study aimed to investigate the association of these factors with BP in adolescents with T1D. Methods: Samples...
Gespeichert in:
| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2024-06, Vol.73 (Supplement_1), p.1 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | Supplement_1 |
| container_start_page | 1 |
| container_title | Diabetes (New York, N.Y.) |
| container_volume | 73 |
| creator | MOHAMMAD, EMAAD LENHERR-TAUBE, NINA MAHMUD, FARID H. MOINEDDIN, RAHIM SOCHETT, ETIENNE B. |
| description | Introduction & Objective: Hypertension is common in type 1 diabetes (T1D). Renin-angiotensin aldosterone system (RAAS) and calcium-phosphate metabolism modulate blood pressure (BP). This study aimed to investigate the association of these factors with BP in adolescents with T1D.
Methods: Samples from 106 T1D (duration 7 years) and 106 healthy controls (HC) (similar age (10-17 years) and sex distribution) were analyzed for 25(OH)D, calcium, phosphate, PTH, FGF-23, klotho, plasma renin activity (PRA), aldosterone and urinary RAAS. Mean of two office blood pressure measurements, unpaired T-test, Chi-square, and linear regression (MLR) were used.
Results: Significant differences between TID and HC, were respectively: sBP (114.71 v 111.41), dBP (66.72 v 63.59), and BMI (22.16 v 20.91 kg/m2). PRA level was lower (0.21 v 1.8) and plasma aldosterone higher (444 v 65); higher urinary angiotensinogen (5.08 v 2.12) and urinary ACE2 activity (271.76 v 69.22) and lower urinary ACE activity (1.17 v 123.30); higher klotho (31.10 v 27.52) and PTH (36.42 v 24.11), lower 25(OH)D (56.94 v 88.42) and calcium (2.43 v 2.51). In T1D, unadjusted MLR; sBP was associated with BMI (p |
| doi_str_mv | 10.2337/db24-1180-P |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_3111273774</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3111273774</sourcerecordid><originalsourceid>FETCH-LOGICAL-c644-ecb856bfdc744b3ddc351c789b5f4372c99734aa0d03d439ba56162ba76327293</originalsourceid><addsrcrecordid>eNotkE1LAzEURYMoWKsr_0DApUSTvMykcVertULRLrpwF_I1OGU6GZMp0n_vDJW3uJvD5b6D0C2jDxxAPnrLBWFsRsnmDE2YAkWAy69zNKGUccKkkpfoKucdpbQcboI-TvQTfm5i9HiTQs6HFLBpPV7FtI-tafDSuD6mjOsWz31sQnah7fFv3X_j7bELmOGX2tjQh3yNLirT5HDzn1O0Xb5uFyuy_nx7X8zXxJVCkODsrCht5Z0UwoL3Dgrm5EzZohIguVNKgjCGegpegLKmKFnJrZHl8A5XMEV3p9ouxZ9DyL3exUMapmYNjDEuQUoxUPcnyqWYcwqV7lK9N-moGdWjLz360qMBvYE_WAJa_Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3111273774</pqid></control><display><type>article</type><title>1180-P: Blood Pressure and Hormonal Factors in Adolescent with Type 1 Diabetes</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>MOHAMMAD, EMAAD ; LENHERR-TAUBE, NINA ; MAHMUD, FARID H. ; MOINEDDIN, RAHIM ; SOCHETT, ETIENNE B.</creator><creatorcontrib>MOHAMMAD, EMAAD ; LENHERR-TAUBE, NINA ; MAHMUD, FARID H. ; MOINEDDIN, RAHIM ; SOCHETT, ETIENNE B.</creatorcontrib><description><![CDATA[Introduction & Objective: Hypertension is common in type 1 diabetes (T1D). Renin-angiotensin aldosterone system (RAAS) and calcium-phosphate metabolism modulate blood pressure (BP). This study aimed to investigate the association of these factors with BP in adolescents with T1D.
Methods: Samples from 106 T1D (duration 7 years) and 106 healthy controls (HC) (similar age (10-17 years) and sex distribution) were analyzed for 25(OH)D, calcium, phosphate, PTH, FGF-23, klotho, plasma renin activity (PRA), aldosterone and urinary RAAS. Mean of two office blood pressure measurements, unpaired T-test, Chi-square, and linear regression (MLR) were used.
Results: Significant differences between TID and HC, were respectively: sBP (114.71 v 111.41), dBP (66.72 v 63.59), and BMI (22.16 v 20.91 kg/m2). PRA level was lower (0.21 v 1.8) and plasma aldosterone higher (444 v 65); higher urinary angiotensinogen (5.08 v 2.12) and urinary ACE2 activity (271.76 v 69.22) and lower urinary ACE activity (1.17 v 123.30); higher klotho (31.10 v 27.52) and PTH (36.42 v 24.11), lower 25(OH)D (56.94 v 88.42) and calcium (2.43 v 2.51). In T1D, unadjusted MLR; sBP was associated with BMI (p <0.005) and plasma phosphate (p <0.005); dBP with BMI (p <0.005), PTH (p = 0.026) and phosphate (p <0.005). Adjusted MLR; sBP was associated with BMI (< 0.005) and dBP with FGF 23 (0.047) and BMI (0.010).
Conclusion: Adolescents with T1D had higher BP and significant differences in RAAS, calcium and vitamin D hormones than HC, suggesting hormonal factors may modulate BP regulation pre-hypertension.]]></description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/db24-1180-P</identifier><language>eng</language><publisher>New York: American Diabetes Association</publisher><subject>25-Hydroxyvitamin D ; Adolescents ; Age composition ; Aldosterone ; Angiotensin ; Angiotensinogen ; Blood pressure ; Calcium (blood) ; Calcium metabolism ; Calcium phosphates ; Diabetes ; Diabetes mellitus (insulin dependent) ; Fibroblast growth factor 23 ; Fibroblast growth factors ; Hypertension ; Klotho protein ; Parathyroid hormone ; Renin ; Teenagers ; Vitamin D</subject><ispartof>Diabetes (New York, N.Y.), 2024-06, Vol.73 (Supplement_1), p.1</ispartof><rights>Copyright American Diabetes Association Jun 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>MOHAMMAD, EMAAD</creatorcontrib><creatorcontrib>LENHERR-TAUBE, NINA</creatorcontrib><creatorcontrib>MAHMUD, FARID H.</creatorcontrib><creatorcontrib>MOINEDDIN, RAHIM</creatorcontrib><creatorcontrib>SOCHETT, ETIENNE B.</creatorcontrib><title>1180-P: Blood Pressure and Hormonal Factors in Adolescent with Type 1 Diabetes</title><title>Diabetes (New York, N.Y.)</title><description><![CDATA[Introduction & Objective: Hypertension is common in type 1 diabetes (T1D). Renin-angiotensin aldosterone system (RAAS) and calcium-phosphate metabolism modulate blood pressure (BP). This study aimed to investigate the association of these factors with BP in adolescents with T1D.
Methods: Samples from 106 T1D (duration 7 years) and 106 healthy controls (HC) (similar age (10-17 years) and sex distribution) were analyzed for 25(OH)D, calcium, phosphate, PTH, FGF-23, klotho, plasma renin activity (PRA), aldosterone and urinary RAAS. Mean of two office blood pressure measurements, unpaired T-test, Chi-square, and linear regression (MLR) were used.
Results: Significant differences between TID and HC, were respectively: sBP (114.71 v 111.41), dBP (66.72 v 63.59), and BMI (22.16 v 20.91 kg/m2). PRA level was lower (0.21 v 1.8) and plasma aldosterone higher (444 v 65); higher urinary angiotensinogen (5.08 v 2.12) and urinary ACE2 activity (271.76 v 69.22) and lower urinary ACE activity (1.17 v 123.30); higher klotho (31.10 v 27.52) and PTH (36.42 v 24.11), lower 25(OH)D (56.94 v 88.42) and calcium (2.43 v 2.51). In T1D, unadjusted MLR; sBP was associated with BMI (p <0.005) and plasma phosphate (p <0.005); dBP with BMI (p <0.005), PTH (p = 0.026) and phosphate (p <0.005). Adjusted MLR; sBP was associated with BMI (< 0.005) and dBP with FGF 23 (0.047) and BMI (0.010).
Conclusion: Adolescents with T1D had higher BP and significant differences in RAAS, calcium and vitamin D hormones than HC, suggesting hormonal factors may modulate BP regulation pre-hypertension.]]></description><subject>25-Hydroxyvitamin D</subject><subject>Adolescents</subject><subject>Age composition</subject><subject>Aldosterone</subject><subject>Angiotensin</subject><subject>Angiotensinogen</subject><subject>Blood pressure</subject><subject>Calcium (blood)</subject><subject>Calcium metabolism</subject><subject>Calcium phosphates</subject><subject>Diabetes</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Fibroblast growth factor 23</subject><subject>Fibroblast growth factors</subject><subject>Hypertension</subject><subject>Klotho protein</subject><subject>Parathyroid hormone</subject><subject>Renin</subject><subject>Teenagers</subject><subject>Vitamin D</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNotkE1LAzEURYMoWKsr_0DApUSTvMykcVertULRLrpwF_I1OGU6GZMp0n_vDJW3uJvD5b6D0C2jDxxAPnrLBWFsRsnmDE2YAkWAy69zNKGUccKkkpfoKucdpbQcboI-TvQTfm5i9HiTQs6HFLBpPV7FtI-tafDSuD6mjOsWz31sQnah7fFv3X_j7bELmOGX2tjQh3yNLirT5HDzn1O0Xb5uFyuy_nx7X8zXxJVCkODsrCht5Z0UwoL3Dgrm5EzZohIguVNKgjCGegpegLKmKFnJrZHl8A5XMEV3p9ouxZ9DyL3exUMapmYNjDEuQUoxUPcnyqWYcwqV7lK9N-moGdWjLz360qMBvYE_WAJa_Q</recordid><startdate>20240614</startdate><enddate>20240614</enddate><creator>MOHAMMAD, EMAAD</creator><creator>LENHERR-TAUBE, NINA</creator><creator>MAHMUD, FARID H.</creator><creator>MOINEDDIN, RAHIM</creator><creator>SOCHETT, ETIENNE B.</creator><general>American Diabetes Association</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20240614</creationdate><title>1180-P: Blood Pressure and Hormonal Factors in Adolescent with Type 1 Diabetes</title><author>MOHAMMAD, EMAAD ; LENHERR-TAUBE, NINA ; MAHMUD, FARID H. ; MOINEDDIN, RAHIM ; SOCHETT, ETIENNE B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c644-ecb856bfdc744b3ddc351c789b5f4372c99734aa0d03d439ba56162ba76327293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Adolescents</topic><topic>Age composition</topic><topic>Aldosterone</topic><topic>Angiotensin</topic><topic>Angiotensinogen</topic><topic>Blood pressure</topic><topic>Calcium (blood)</topic><topic>Calcium metabolism</topic><topic>Calcium phosphates</topic><topic>Diabetes</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Fibroblast growth factor 23</topic><topic>Fibroblast growth factors</topic><topic>Hypertension</topic><topic>Klotho protein</topic><topic>Parathyroid hormone</topic><topic>Renin</topic><topic>Teenagers</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOHAMMAD, EMAAD</creatorcontrib><creatorcontrib>LENHERR-TAUBE, NINA</creatorcontrib><creatorcontrib>MAHMUD, FARID H.</creatorcontrib><creatorcontrib>MOINEDDIN, RAHIM</creatorcontrib><creatorcontrib>SOCHETT, ETIENNE B.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOHAMMAD, EMAAD</au><au>LENHERR-TAUBE, NINA</au><au>MAHMUD, FARID H.</au><au>MOINEDDIN, RAHIM</au><au>SOCHETT, ETIENNE B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1180-P: Blood Pressure and Hormonal Factors in Adolescent with Type 1 Diabetes</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><date>2024-06-14</date><risdate>2024</risdate><volume>73</volume><issue>Supplement_1</issue><spage>1</spage><pages>1-</pages><issn>0012-1797</issn><eissn>1939-327X</eissn><abstract><![CDATA[Introduction & Objective: Hypertension is common in type 1 diabetes (T1D). Renin-angiotensin aldosterone system (RAAS) and calcium-phosphate metabolism modulate blood pressure (BP). This study aimed to investigate the association of these factors with BP in adolescents with T1D.
Methods: Samples from 106 T1D (duration 7 years) and 106 healthy controls (HC) (similar age (10-17 years) and sex distribution) were analyzed for 25(OH)D, calcium, phosphate, PTH, FGF-23, klotho, plasma renin activity (PRA), aldosterone and urinary RAAS. Mean of two office blood pressure measurements, unpaired T-test, Chi-square, and linear regression (MLR) were used.
Results: Significant differences between TID and HC, were respectively: sBP (114.71 v 111.41), dBP (66.72 v 63.59), and BMI (22.16 v 20.91 kg/m2). PRA level was lower (0.21 v 1.8) and plasma aldosterone higher (444 v 65); higher urinary angiotensinogen (5.08 v 2.12) and urinary ACE2 activity (271.76 v 69.22) and lower urinary ACE activity (1.17 v 123.30); higher klotho (31.10 v 27.52) and PTH (36.42 v 24.11), lower 25(OH)D (56.94 v 88.42) and calcium (2.43 v 2.51). In T1D, unadjusted MLR; sBP was associated with BMI (p <0.005) and plasma phosphate (p <0.005); dBP with BMI (p <0.005), PTH (p = 0.026) and phosphate (p <0.005). Adjusted MLR; sBP was associated with BMI (< 0.005) and dBP with FGF 23 (0.047) and BMI (0.010).
Conclusion: Adolescents with T1D had higher BP and significant differences in RAAS, calcium and vitamin D hormones than HC, suggesting hormonal factors may modulate BP regulation pre-hypertension.]]></abstract><cop>New York</cop><pub>American Diabetes Association</pub><doi>10.2337/db24-1180-P</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-1797 |
| ispartof | Diabetes (New York, N.Y.), 2024-06, Vol.73 (Supplement_1), p.1 |
| issn | 0012-1797 1939-327X |
| language | eng |
| recordid | cdi_proquest_journals_3111273774 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 25-Hydroxyvitamin D Adolescents Age composition Aldosterone Angiotensin Angiotensinogen Blood pressure Calcium (blood) Calcium metabolism Calcium phosphates Diabetes Diabetes mellitus (insulin dependent) Fibroblast growth factor 23 Fibroblast growth factors Hypertension Klotho protein Parathyroid hormone Renin Teenagers Vitamin D |
| title | 1180-P: Blood Pressure and Hormonal Factors in Adolescent with Type 1 Diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T20%3A52%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=1180-P:%20Blood%20Pressure%20and%20Hormonal%20Factors%20in%20Adolescent%20with%20Type%201%20Diabetes&rft.jtitle=Diabetes%20(New%20York,%20N.Y.)&rft.au=MOHAMMAD,%20EMAAD&rft.date=2024-06-14&rft.volume=73&rft.issue=Supplement_1&rft.spage=1&rft.pages=1-&rft.issn=0012-1797&rft.eissn=1939-327X&rft_id=info:doi/10.2337/db24-1180-P&rft_dat=%3Cproquest_cross%3E3111273774%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3111273774&rft_id=info:pmid/&rfr_iscdi=true |