1180-P: Blood Pressure and Hormonal Factors in Adolescent with Type 1 Diabetes

Introduction & Objective: Hypertension is common in type 1 diabetes (T1D). Renin-angiotensin aldosterone system (RAAS) and calcium-phosphate metabolism modulate blood pressure (BP). This study aimed to investigate the association of these factors with BP in adolescents with T1D. Methods: Samples from 106 T1D (duration 7 years) and 106 healthy controls (HC) (similar age (10-17 years) and sex distribution) were analyzed for 25(OH)D, calcium, phosphate, PTH, FGF-23, klotho, plasma renin activity (PRA), aldosterone and urinary RAAS. Mean of two office blood pressure measurements, unpaired T-test, Chi-square, and linear regression (MLR) were used. Results: Significant differences between TID and HC, were respectively: sBP (114.71 v 111.41), dBP (66.72 v 63.59), and BMI (22.16 v 20.91 kg/m2). PRA level was lower (0.21 v 1.8) and plasma aldosterone higher (444 v 65); higher urinary angiotensinogen (5.08 v 2.12) and urinary ACE2 activity (271.76 v 69.22) and lower urinary ACE activity (1.17 v 123.30); higher klotho (31.10 v 27.52) and PTH (36.42 v 24.11), lower 25(OH)D (56.94 v 88.42) and calcium (2.43 v 2.51). In T1D, unadjusted MLR; sBP was associated with BMI (p