Solvent-free Markovnikov hydroamination of vinylarenes with carboxamides: a heterogeneous catalytic approach using Hβ zeolite

The synthesis of carbon-heteroatom bonds, a crucial element in organic chemistry, often requires obstacles in direct amine integration with olefins. This study introduces a sustainable approach for producing nitrogen-bearing molecules through the Markovnikov hydroamination of vinylarenes with carboxamides, employing Hβ zeolite as an effective heterogeneous catalyst in a solvent-free environment. We explored the method's adaptability over various substrates, achieving consistently high yields and regioselectivity in the resultant products. The procedure's scalability to gram-level production and the catalyst's sustainable reuse for multiple cycles (up to five) underscores its viability for industrial application, indicating a significant increase in organic synthesis activity. A novel heterogeneous catalytic method has been developed to facilitate the intermolecular Markovnikov hydroamination of vinylarenes with benzamides using Hβ zeolite in a solvent-free environment.