Nickel‐Catalyzed Regio‐ and Stereoselective Reductive Alkylative Cyclization of 1,6‐Enynes with Alkyl Bromides

Nickel‐Catalyzed Regio‐ and Stereoselective Reductive Alkylative Cyclization of 1,6‐Enynes with Alkyl Bromides

A nickel‐catalyzed reductive alkylative cyclization of 1,6‐enynes with alkyl bromides has been developed. This transformation avoids the use of stoichiometric organometallic reagents and introduces alkyl groups regio‐ and stereoselectively into the products. This method provides a platform for the s...

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Veröffentlicht in:Advanced synthesis & catalysis 2024-09, Vol.366 (18), p.3802-3807
Hauptverfasser: Xing, Yunxin, Tian, Zhu, Shen, Kun
Format: Artikel
Sprache:eng
Schlagworte:
1,6-enyne
Alkylation
Bromides
Chemical synthesis
Cyclization
Natural products
Nickel
Reagents
Reductive cross-coupling
Stereoselectivity
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Zusammenfassung:A nickel‐catalyzed reductive alkylative cyclization of 1,6‐enynes with alkyl bromides has been developed. This transformation avoids the use of stoichiometric organometallic reagents and introduces alkyl groups regio‐ and stereoselectively into the products. This method provides a platform for the synthesis of carbo‐ and heterocycles that are widely found in many natural products and biologically active molecules.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202400575