Solubility enhancement of β-ionone with lipidic, amphiphilic, and inclusion complex: extensive polymeric biomaterials to develop formulations for poorly soluble drugs

Combinatorial chemistry and drug design have produced more lipophilic, heavier, and less water soluble drugs in recent years. It is more difficult to find the best drug delivery system for them. In this area of technology and drug development, new strategies are applied to develop novel drug moieties and improve their water solubility. One of the main obstacles is the use of poorly water soluble chemicals in formulation. Beta-ionone ( β -ionone) is utilised to target many forms of cancer and has been shown to have anticancer potential in recent studies, however it has poor water solubility. The goal of the current study was to enhance the solubility of beta-ionone using various carrier materials like non-ionic water-dispersible surfactant Gelucire® 50/13 (polyoxylglycerides) which self-emulsifies in aqueous media forming a fine micro-dispersion. Another amphiphilic material, Soluplus® (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer was used to enhance the solubility of beta-ionone. Further, Hydroxypropyl- β -Cyclodextrin inclusion complex was also prepared and evaluated to check the improvement in the solubility of beta-ionone. Finally, the performance of these carries was checked by developing the pellet formulation. An appropriate formulation offers a method to improve the solubility, dissolution, and bioavailability of β -ionone. When compared to alternative cancer treatment options, this formulation may aid to improve patient compliance and the drug's effectiveness. The pellet formulation developed utilising HP- β -CD has produced outstanding results and may be more stable due to the inclusion-capabilities, complexes. Graphical abstract