Antitumor properties of novel 2-(1 H -benzoimidazol-2-yland 2-benzothiazol-2-yl)-3-(5-phenylfuran-2-yl)-acrylonitriles derivatives

The synthesis and antitumor activity determination of some novel 2-(1H-benzoimidazol-2-yland 2-benzothiazol2-yl)-3-(5-phenylfuran-2-yl)-acrylonitrilesderivatives are described. By the reaction of 5–arylfurfurals with 1Hbenzimidazol-2-yl) acetonitrile, benzthiazol-2-ylacetonitrile and (4-arylthiazol-2-yl)-acetonitrile were synthesed 3-(5-arylfuran-2-yl)acrylonitrile derivatives. The structure of synthesized compounds was confirmed by elemental analysis and 1H NMR spectroscopy. Within the framework of the International Research Program DTP (Developmental Therapeutic Program) of the National Cancer Institute's (NCI, Betezda, Merilend, USA) antitumor activity screening of synthesized compounds was carried out. It was established that these compounds are promising to search as anti-cancer agents.