Radiolabeling, Characterization, and In Vitro Cell Culture Studies of Donepezil-Loaded Niosome Formulations For Brain Imaging

SUMMARY Dementia has posed a significant public health challenge for aging populations in developed countries for many years. Early diagnosis enables patients to seek early intervention with symptomatic treatment, lifestyle changes to maintain quality of life, and risk-reduction strategies that can clinically reduce cognitive, functional, and behavioral decline (Porsteinsson et al., 2021). [...]efforts towards developing and utilizing such agents are growing rapidly. Characterization of niosome formulations Particle size, polydispersity index, and zeta potential At room temperature, the Malvern Zetasizer (Malvern Nano ZS, Malvern, UK) was used to determine the mean diameters, polydispersity index values, and Zeta potential of niosomes.