Hypocretin receptor antagonists prevent opioid addiction

Hypocretin receptor antagonists prevent opioid addiction

The opioid abuse epidemic is a major health concern that requires new pain management strategies. Findings now show that suvorexant, a dual hypocretin receptor antagonist, reverses the anatomical and circuit alterations induced by opioids and decreases addictive behavior while maintaining the analge...

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Veröffentlicht in:Nature mental health 2024-09, Vol.2 (9), p.1008-1009
Hauptverfasser: Fraigne, Jimmy J., Peever, John H.
Format: Artikel
Sprache:eng
Schlagworte:
Addictions
Addictive behaviors
Analgesics
Behavior
Drug abuse
Hypothalamus
Mental health
Morphine
Morphology
Narcotics
Neurons
Pain management
Sleep disorders
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Zusammenfassung:The opioid abuse epidemic is a major health concern that requires new pain management strategies. Findings now show that suvorexant, a dual hypocretin receptor antagonist, reverses the anatomical and circuit alterations induced by opioids and decreases addictive behavior while maintaining the analgesic properties of the drugs.
ISSN:2731-6076
2731-6076
DOI:10.1038/s44220-024-00300-7