Synthesis and antidiabetic test of Cu(II)-glycine complex compounds

Copper(II) compounds are known to have the ability to be an antidiabetic supplement. The aim of this study is to obtain the results of the synthesis of Cu(II)-glycine complex compounds and test the activity of glucose levels in the blood. The synthesis of the Cu(II)-glycine complex is carried out by reacting copper(II) metals with amino acid glycine ligands using reflux and freeze dry methods. The synthesized compounds were characterized by UV-Vis spectrophotometer and IR spectrophotometer. The results of UV-Vis characterization showed that the absorption of the wavelengths of the Cu(II)-glycine complexes experienced a hipsochromic shift from the absorption of metal compounds CuCl2.2H2O. The results of the IR spectrum of the Cu(II)-glycine complex showed uptake of Cu-O and Cu-N in the area of 592.79 cm−1 and 513.94 cm−1. The Cu(II)-glycine complex compounds are blue with a yield of 85.92%. The synthesized compounds obtained were followed by in vivo antidiabetic activity testing. The data obtained was tested using One Way ANOVA, which showed significant results in reducing blood sugar levels. The best dosage of Cu(II)- glycin complex compounds is at 200 µg/KgBW, which can reduce blood sugar levels by 41.33%.