2014-LB: Association between Variants in Genes Involved in the Metabolism of Uric Acid and the Risk of Type 2 Diabetes

Introduction & Objective: Epidemiological and experimental evidence suggests that hyperuricemia is involved in the pathophysiology of type 2 diabetes (T2D), inducing insulin resistance or beta cell failure. Therefore, our objective was to investigate a possible association between variants in genes related to uric acid metabolism and T2D in a case-control study design. Methods: Our sample consisted of 624 T2D patients from Greece and 356 normoglycemic, ancestry-matched controls. In the control group, individuals over 65 years of age were included to minimize the probability that T2D will present at a later stage in their life. The samples were genotyped on Illumina Human PsychArray 24 v1.1. We focused our investigation on 30 genes involved in the metabolism of uric acid. We conducted allelic and genotypic tests using PLINK v1.9. The significance of the association was determined using permutation for each type of test. Furthermore, we performed haplotypic tests using BEAGLE v3.2.3. SNPs with association P-values