415-P: Different Diabetic Kidney Disease (DKD) Phenotypes and Urinary Fetuin-A Levels in Subjects with Type 2 Diabetes

415-P: Different Diabetic Kidney Disease (DKD) Phenotypes and Urinary Fetuin-A Levels in Subjects with Type 2 Diabetes

Introduction & Objective: The hepatokine fetuin-A is associated with insulin resistance and promotes inflammation in T2D, contributing to the development of DKD. In this observational, single-center study, we evaluated the potential of this novel urinary biomarker in differentiating DKD phenotyp...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2024-06, Vol.73, p.1
Hauptverfasser: Garofolo, Monia, Lucchesi, Daniela, Giambalvo, Massimo, Capobianco, Martina, Mancini, Gabriele, Del Prato, Stefano, Marchetti, Piero, Penno, Giuseppe
Format: Artikel
Sprache:eng
Schlagworte:
Creatinine
Diabetes
Diabetes mellitus (non-insulin dependent)
Dyslipidemia
Epidermal growth factor receptors
Insulin resistance
Kidney diseases
Phenotypes
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Zusammenfassung:Introduction & Objective: The hepatokine fetuin-A is associated with insulin resistance and promotes inflammation in T2D, contributing to the development of DKD. In this observational, single-center study, we evaluated the potential of this novel urinary biomarker in differentiating DKD phenotypes in T2D subjects. Methods: DKD phenotypes were defined based on increased albuminuria (uACR >30 mg/g) and/or reduced CKD-EPI eGFR (
ISSN:0012-1797
1939-327X
DOI:10.2337/db24-415-P