446-P: Prognostic Role of Type 2 Diabetes Mellitus in Minor vs. Major Atherosclerosis

The impact of diabetes on major cardiovascular events (MACE) in relation to the extent of pre-existing atherosclerotic disease remains unclear. In this study we compare the impact of T2DM on MACE in patients with two different states of atherosclerosis: minor coronary atherosclerosis (minAS) and peripheral artery disease, one of the most severe manifestations of major atherosclerosis (majAS). We included 1238 patients from two long-term prospective cohort studies. Patients underwent coronary angiography for the allocation to a control group without any lumen irregularities (n=332) or a minAS group with lumen irregularities but no significant coronary stenoses ≥50% at coronary angiography (n=425). Patients with sonographically proven peripheral artery disease were allocated to the majAS group (n= 481). Over a mean time-period of 7.7 years major cardiovascular events (MACE) were recorded. Overall, MACE were recorded in 681 (51%) patients. T2DM significantly increased the risk of MACE both among patients with minAS (22.0% vs. 32.4%; p=0.023) and majAS (50.6% vs. 67.1%; p