241-OR: Health-Related Quality of Life and Burden of Type 1 Diabetes and Severe Hypoglycemia in Adult Continuous Glucose Monitor Users

Introduction & Objective: Continuous glucose monitors (CGM) help manage glycemic control, but severe hypoglycemic events (SHE) remain challenging for adults with T1D. SHE may also reduce health-related quality of life (HRQoL) and increase humanistic and economic burden. Published literature on HRQoL in adult CGM users with T1D is limited. Methods: Adult (≥18 years) CGM users from the T1D Exchange Registry completed an online self-report survey with SHE experiences, impaired awareness of hypoglycemia (IAH, Modified Gold Score), and patient-reported outcome measures (PROM). SHE cohorts were created based on SHE frequency in the past 12 months and presence/absence of IAH: problematic SHE, single SHE/no IAH, undetermined IAH, and no SHE (defined in the Table). Descriptive results (mean, SD) of PROM are reported overall and by SHE cohort. Results: Overall, participants (N=1,847) were 45.9 years old, had T1D for 29 years (SD 15.1), and reported 1.8 SHE (SD 13.3) in the past year. Variability in patient-reported burden and HRQoL impairment was observed across cohorts. The problematic SHE cohort reported the highest mean burden and impairment (Table). Conclusion: Despite advanced diabetes technology utilization, individuals with T1D and SHE experience substantial negative impacts of HRQoL, highlighting the significant unmet need in this patient population.