Catalytic thiomethylation of indoles

The catalysis of direct thiomethylation of 1 H -indole and tryptophan under the action of the formaldehyde—mercaptan reagent system in the presence of acids and bases, phosphorus oxide and the oxidative system I 2 /NaOH was studied. A mechanism for the catalysis of the multicomponent thiomethylation...

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Veröffentlicht in:	Russian chemical bulletin 2024-07, Vol.73 (7), p.1962-1967
Hauptverfasser:	Akhmetova, V. R., Leont’ev, D. V., Akhmadiev, N. S., Paramonov, E. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Chemistry Chemistry and Materials Science Chemistry/Food Science Full Articles Indoles Inorganic Chemistry Organic Chemistry Phosphorus oxides Reagents Spectrometry Tryptophan
Online-Zugang:	Volltext
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Zusammenfassung:	The catalysis of direct thiomethylation of 1 H -indole and tryptophan under the action of the formaldehyde—mercaptan reagent system in the presence of acids and bases, phosphorus oxide and the oxidative system I 2 /NaOH was studied. A mechanism for the catalysis of the multicomponent thiomethylation reaction was proposed based on the results of mass spectrometric study of intermediate compounds.
ISSN:	1066-5285 1573-9171
DOI:	10.1007/s11172-024-4315-6