Synthesis and Antimicrobial Properties of Quaternary Ammonium Salts with Two Propargyl Groups

Several dipropargylic quaternary ammonium salts were synthesized by the reaction of methyldipropargylamine with alkyl esters (C 8 -C 12 ) of chloroacetic acid or haloalkanes with the number of carbon atoms C 8 –C 10 . The synthesized N -methyl- N , N -di(prop-2-yn-1-yl)alkan-1-ammonium halides (bromide and iodides), and N -(2-(alkoxy)-2-oxoethyl)- N -methyl- N -(prop-2-yn-1-yl)prop-2-yn-1-ammonium chlorides exhibit high antibacterial activity against gram-positive ( Stаphylococcus aureus 209p and Bacillus subtilis 6633), gram-negative ( Shigella Flexneri 6858 and Escherichia coli 0-55) microorganisms and antifungal activity against ( Candida Albicans, Saccharomyces cerevisiae, and Saccharomyces boulardii ).