Isoxazole group directed Rh()-catalyzed alkynylation using TIPS-EBX

Isoxazole group directed Rh()-catalyzed alkynylation using TIPS-EBX

A highly effective isoxazole directed ortho C-H alkynylation has been developed. Rhodium( iii ) catalyzed direct di-(and/or mono) alkynylation using a hypervalent iodine reagent (TIPS-EBX) is reported. The reaction proceeds with a wide substrate scope under benign conditions. Preliminary mechanistic...

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Veröffentlicht in:Organic & biomolecular chemistry 2024-08, Vol.22 (34), p.6922-6927
Hauptverfasser: Das, Sukanya, Datta, Tanmoy, Sk, Md. Abbasuddin, Roy, Brindaban, Nandi, Raj K
Format: Artikel
Sprache:eng
Schlagworte:
Chelation
Iodine
Reagents
Rhodium
Substrates
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Zusammenfassung:A highly effective isoxazole directed ortho C-H alkynylation has been developed. Rhodium( iii ) catalyzed direct di-(and/or mono) alkynylation using a hypervalent iodine reagent (TIPS-EBX) is reported. The reaction proceeds with a wide substrate scope under benign conditions. Preliminary mechanistic studies support this chelation assisted C-H alkynylation. Ortho C-H alkynylation of arenes using TIPS-EBX.
ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/d4ob00797b