Highly Stereoselective Synthesis of 1,3‐Enynes via Aryl to Vinyl 1,4‐Palladium Migration/Sonogashira Coupling Sequence

Highly Stereoselective Synthesis of 1,3‐Enynes via Aryl to Vinyl 1,4‐Palladium Migration/Sonogashira Coupling Sequence

Alkynylation of alkenyl bromoarenes via aryl to vinyl 1,4‐palladium migration/copper‐free Sonogashira coupling sequence has been developed. This approach provides a facile methodology for the highly stereoselective synthesis of multi‐substituted 1,3‐enynes in good to excellent yields and regioselect...

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Veröffentlicht in:ChemCatChem 2024-08, Vol.16 (16), p.n/a
Hauptverfasser: Chen, Zheng‐Yu, Ji, Xiao‐Ming, Wang, Xue, Asgari, Motahareh, Fu, Jian‐Guo, Zhang, Shu‐Sheng, Feng, Chen‐Guo
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
Coupling
C−H Functionalization
Enyne
Palladium
Palladium Migration
Sonogashira Reaction
Stereoselectivity
Synthesis
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Zusammenfassung:Alkynylation of alkenyl bromoarenes via aryl to vinyl 1,4‐palladium migration/copper‐free Sonogashira coupling sequence has been developed. This approach provides a facile methodology for the highly stereoselective synthesis of multi‐substituted 1,3‐enynes in good to excellent yields and regioselectivities. Sonogashira Coupling after 1,4‐Palladium Migration: An aryl to vinyl 1,4‐palladium migration/ Sonogashira Coupling sequence has been achieved for the highly stereoselective synthesis of multi‐substituted 1,3‐enynes.
ISSN:1867-3880
1867-3899
DOI:10.1002/cctc.202400478