Synthesis of Novel Spirochromanone/1,2,3-Triazole Hybrid Heterocycles as Potential Antimicrobial Agents

Synthesis of Novel Spirochromanone/1,2,3-Triazole Hybrid Heterocycles as Potential Antimicrobial Agents

A series of new hybrid spirochromanone-1,2,3-triazole derivatives have been synthesized by employing a Cu(I)-catalyzed azide-alkyne [3+2] cycloaddition reaction. All compounds were characterized using 1 H NMR, 13 C NMR and HRMS methods. In addition, all synthesized compounds were tested in vitro for...

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Veröffentlicht in:Russian journal of general chemistry 2024-06, Vol.94 (6), p.1436-1442
Hauptverfasser: Raju, M., Hemasri, Y., Rao, Y. Jayaprakash
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cycloaddition
In vitro methods and tests
NMR
Nuclear magnetic resonance
Triazoles
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Zusammenfassung:A series of new hybrid spirochromanone-1,2,3-triazole derivatives have been synthesized by employing a Cu(I)-catalyzed azide-alkyne [3+2] cycloaddition reaction. All compounds were characterized using 1 H NMR, 13 C NMR and HRMS methods. In addition, all synthesized compounds were tested in vitro for antimicrobial activity.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363224060203