Quantification of Multi-Compartment Flow with Spectral Diffusion MRI

Quantification of Multi-Compartment Flow with Spectral Diffusion MRI

Purpose: Estimation of multi-compartment intravoxel flow in fD in ml/100g/min with multi-b-value diffusion weighted imaging and a multi-Gaussian model in the kidneys. Theory and Methods: A multi-Gaussian model of intravoxel flow using water transport time to quantify fD is presented and simulated. M...

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Veröffentlicht in:arXiv.org 2024-08
Hauptverfasser: Liu, Mira M, Dyke, Jonathan, Gladytz, Thomas, Jasse, Jonas, Bolger, Ian, Calle, Sergio, Pavaluri, Swathi, Crews, Tanner, Seshan, Surya, Salvatore, Steven, Stillman, Isaac, Muthukumar, Thangamani, Taouli, Bachir, Farouk, Samira, Lewis, Sara, Bane, Octavia
Format: Artikel
Sprache:eng
Schlagworte:
Anisotropy
Atrophy
Correlation coefficients
Fibrosis
Kidneys
Medical imaging
Parameters
Regularization
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Zusammenfassung:Purpose: Estimation of multi-compartment intravoxel flow in fD in ml/100g/min with multi-b-value diffusion weighted imaging and a multi-Gaussian model in the kidneys. Theory and Methods: A multi-Gaussian model of intravoxel flow using water transport time to quantify fD is presented and simulated. Multi-compartment anisotropic DWI signal is simulated analyzed with (1) a rigid bi-exponential, (2) a rigid tri-exponential, and (3) diffusion spectrum imaging model of intravoxel incoherent motion (spectral diffusion). The application is demonstrated in a two-center study of 54 kidney allografts with 9 b-value advanced DWI that were split by function (CKD-EPI 2021 eGFR
ISSN:2331-8422