Pinhão Coat (Araucaria angustifolia (Bertol.) Kuntze) Nanosuspension as a Potential Additive in Cosmetic Formulations with Wound Healing Effect

Purpose Development of a sustainable route to value pinhão ( Araucaria angustifolia (Bertol.) Kuntze) coat through mechanical defibrillation process and employment as an additive in cosmetic formulations. Methods The pinhão coat nanosuspension (PCN) was added to the Lanette® base at concentrations of 0.5, 1.0, 1.5, and 2.0%. Subsequently, the PCN-based formulations were evaluated concerning their appearance, physiochemical aspects (pH, spreadability, and stability tests), rheological behavior, cytotoxicity, and wound closure capacity. Results The outcomes showed that the PCN addition conferred a light brown milky color to the lotions, besides decreasing the pH values and increasing the spreadability compared to the control formulations. Related to the rheological analysis, the lotions with PCN displayed pseudoplastic behavior, an aspect of strong gel, and were also stable through the thermomechanical analysis. The cell viability analysis showed no cytotoxicity of the PCN-based formulations at concentrations inferior to 0.05 mg/mL. Furthermore, the in vitro scratch wound assay revealed that the presence of PCN (1.5 and 2.0%) promoted a complete wound contraction after 72 h of treatment. Conclusion The study demonstrated a sustainable alternative to apply pinhão by-product in cosmetic formulation with wound-healing effects. Graphic Abstract