Cytotoxicity Study of nHAP/Chitosan and nHAP/Cellulose Composite Scaffolds Synthesized via Co-Precipitation for Bone Tissue Engineering

The main purpose of this study is to synthesize nano-hydroxyapatite/cellulose (nHAP/Cel) and nano-hydroxyapatite/chitosan (nHAP/CS) scaffolds via co-precipitation method for bone tissue engineering due to their suitable biocompatibility, cytotoxicity and mechanical properties. The characterizations...

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Veröffentlicht in:Journal of biomimetics, biomaterials and biomedical engineering biomaterials and biomedical engineering, 2023-05, Vol.60, p.1-10
Hauptverfasser: Fathi, Fereshteh, Shokrzadeh, Mohammad, Motafeghi, Farzaneh, Farhadyar, Nazanin
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Sprache:eng
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Zusammenfassung:The main purpose of this study is to synthesize nano-hydroxyapatite/cellulose (nHAP/Cel) and nano-hydroxyapatite/chitosan (nHAP/CS) scaffolds via co-precipitation method for bone tissue engineering due to their suitable biocompatibility, cytotoxicity and mechanical properties. The characterizations of these scaffolds were investigated by Infrared absorption spectra (FT-IR), X-ray Diffraction (XRD), and Scanning Electron Microscope (SEM). The cytotoxicity of these nanoparticles was evaluated with bone marrow cell using the 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazoliumbromide) (MTT) assay. The porosity of scaffolds was estimated 87%. The results indicate that the nano composite scaffolds have good morphology, tissue biocompatibility and biodegradability to be used for tissue engineering.
ISSN:2296-9837
2296-9845
2296-9845
DOI:10.4028/p-14k07c