New perspectives on arteriosclerosis treatment using nanoparticles and mesenchymal stem cells
Arteriosclerosis (AS) presents a significant global health challenge, demanding innovative therapeutic strategies. This review explores the potential of nanoparticles (NPs) and mesenchymal stem cells (MSCs) as promising modalities for treating AS. NPs enable targeted drug delivery, while MSCs posses...
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| Veröffentlicht in: | Discover Applied Sciences 2024-07, Vol.6 (8), p.411, Article 411 |
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| creator | Farokhi, Simin Razavi, Zahra-Sadat Mavaei, Maryamosadat Shadab, Alireza Afkhami, Hamed Sardarabadi, Hadi |
| description | Arteriosclerosis (AS) presents a significant global health challenge, demanding innovative therapeutic strategies. This review explores the potential of nanoparticles (NPs) and mesenchymal stem cells (MSCs) as promising modalities for treating AS. NPs enable targeted drug delivery, while MSCs possess immunomodulatory and regenerative capabilities. We discuss recent advances in NP-based drug delivery systems tailored for AS treatment and highlight MSCs’ roles in modulating inflammation and promoting vascular repair. Additionally, we examine the synergistic effects of combining NPs and MSCs for enhanced therapeutic outcomes. Furthermore, this paper provides insights into targeting endothelial cells, T-cells, macrophages, lipid levels, and plaques in AS using MSCs. It also reviews various types of metal-based and non-metallic NPs utilized in AS therapy. This comprehensive overview underscores the potential synergies between MSCs and NPs in cardiovascular disease therapy, emphasizing the need for further research to fully realize their therapeutic implications.
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| doi_str_mv | 10.1007/s42452-024-06113-8 |
| format | Article |
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Graphical Abstract</description><subject>Applied and Technical Physics</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cell growth</subject><subject>Chemistry/Food Science</subject><subject>Cholesterol</subject><subject>Coronary vessels</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Earth Sciences</subject><subject>Endothelial cells</subject><subject>Engineering</subject><subject>Environment</subject><subject>Global health</subject><subject>Heart</subject><subject>Immune system</subject><subject>Immunomodulation</subject><subject>Inflammation</subject><subject>Lipids</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Materials Science</subject><subject>Medical innovations</subject><subject>Mesenchymal stem cells</subject><subject>Nanoparticles</subject><subject>Public health</subject><subject>Review</subject><subject>Reviews</subject><subject>Risk factors</subject><subject>Smooth muscle</subject><subject>Statins</subject><subject>Stem cells</subject><subject>Synergistic effect</subject><subject>Vein & artery diseases</subject><issn>3004-9261</issn><issn>2523-3963</issn><issn>3004-9261</issn><issn>2523-3971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LxDAQhosouKz7BzwFPFfz1TQ5yuIXLHrRo4Q0nV0rbVozWWX_vdEV9ORp5vC87zBPUZwyes4orS9QclnxknJZUsWYKPVBMROUytJwxQ7_7MfFArFraCUlF0qYWfF8Dx9kgogT-NS9A5IxEBcTxG5E30McsUOSIrg0QEhki13YkODCOGWqywQSF1oyAELwL7vB9QQTDMRD3-NJcbR2PcLiZ86Lp-urx-VtuXq4uVterkrPpUylrk3ttGJKa6VVWzXc1JorL0XFa1VVtNaC0daAbhU45rVrnDJCN8zk6aSYF2f73imOb1vAZF_HbQz5pBU0FxsqaJUpvqd8_gojrO0Uu8HFnWXUfpm0e5M2m7TfJq3OIbEPYYbDBuJv9T-pT-MrdpU</recordid><startdate>20240729</startdate><enddate>20240729</enddate><creator>Farokhi, Simin</creator><creator>Razavi, Zahra-Sadat</creator><creator>Mavaei, Maryamosadat</creator><creator>Shadab, Alireza</creator><creator>Afkhami, Hamed</creator><creator>Sardarabadi, Hadi</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FG</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>L6V</scope><scope>M2P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope></search><sort><creationdate>20240729</creationdate><title>New perspectives on arteriosclerosis treatment using nanoparticles and mesenchymal stem cells</title><author>Farokhi, Simin ; 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| subjects | Applied and Technical Physics Arteriosclerosis Atherosclerosis Cardiovascular disease Cardiovascular diseases Cell growth Chemistry/Food Science Cholesterol Coronary vessels Cytokines Diabetes Drug delivery Drug delivery systems Earth Sciences Endothelial cells Engineering Environment Global health Heart Immune system Immunomodulation Inflammation Lipids Lymphocytes Lymphocytes T Macrophages Materials Science Medical innovations Mesenchymal stem cells Nanoparticles Public health Review Reviews Risk factors Smooth muscle Statins Stem cells Synergistic effect Vein & artery diseases |
| title | New perspectives on arteriosclerosis treatment using nanoparticles and mesenchymal stem cells |
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