Study of Iron Complex Photosensitizer with Hollow Double‐Shell Nano Structure Used to Enhance Ferroptosis and Photodynamic Therapy (Small 30/2024)

Study of Iron Complex Photosensitizer with Hollow Double‐Shell Nano Structure Used to Enhance Ferroptosis and Photodynamic Therapy (Small 30/2024)

Ferroptosis Therapy In article number 2309086, Baofen Ye, Yue Wang, Ran Yan, and co‐works developed a nanophotosensitizer IR783‐Fe@MnO2‐HA, a hyaluronic acid‐encapsulated iron complex photosensitizer with a hollow double‐shell nanostructure. This nanophotosensitizer targets the CD44 receptor, releas...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-07, Vol.20 (30), p.n/a
Hauptverfasser: Cai, Xinrui, Liu, Weixing, Zhang, Jiahao, Li, Zhongrui, Liu, Mengkang, Hu, Shuo, Luo, Jun, Peng, Kai, Ye, Baofen, Wang, Yue, Yan, Ran
Format: Artikel
Sprache:eng
Schlagworte:
ferroptosis
Hyaluronic acid
Iron
Manganese dioxide
photodynamic therapy
photosensitizer
Synergistic effect
tumor microenvironment
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Zusammenfassung:Ferroptosis Therapy In article number 2309086, Baofen Ye, Yue Wang, Ran Yan, and co‐works developed a nanophotosensitizer IR783‐Fe@MnO2‐HA, a hyaluronic acid‐encapsulated iron complex photosensitizer with a hollow double‐shell nanostructure. This nanophotosensitizer targets the CD44 receptor, releases Fe3+ and IR783 in acidic conditions, enhances the Fenton reaction, induces ferroptosis, and exhibits tumor‐targeting ability and efficient tumor inhibition in vivo due to the synergistic effects of photodynamic and ferroptosis antitumor therapies.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202470231