Guiding Stem Cell Tenogenesis by Modulation of Growth Factor Signaling and Cell‐Scale Biophysical Cues in Bioengineered Constructs (Adv. Funct. Mater. 29/2024)

Guiding Stem Cell Tenogenesis by Modulation of Growth Factor Signaling and Cell‐Scale Biophysical Cues in Bioengineered Constructs (Adv. Funct. Mater. 29/2024)

Stem Cell Tenogenesis In article number 2312961, Manuela E. Gomes, Rui M. A. Domingues, and co‐workers combine endogenous growth factor sequestration by molecularly imprinted nanoparticles with microcontact guidance by magnetic microfibers inside bioinspired hydrogel systems. Simultaneous control ov...

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Veröffentlicht in:Advanced functional materials 2024-07, Vol.34 (29), p.n/a
Hauptverfasser: Teixeira, Simão P. B., Pardo, Alberto, Bakht, Syeda M., Gomez‐Florit, Manuel, Reis, Rui L., Gomes, Manuela E., Domingues, Rui M. A.
Format: Artikel
Sprache:eng
Schlagworte:
Adipose tissue
Bioengineering
biomimetics
Growth factors
hydrogels
Microfibers
microstructures
molecular imprinting
Robust control
Stem cells
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Zusammenfassung:Stem Cell Tenogenesis In article number 2312961, Manuela E. Gomes, Rui M. A. Domingues, and co‐workers combine endogenous growth factor sequestration by molecularly imprinted nanoparticles with microcontact guidance by magnetic microfibers inside bioinspired hydrogel systems. Simultaneous control over biochemical and biophysical cues synergistically promotes a more robust tenogenic commitment of adipose tissue‐derived stem cells. The principles of scalability and cost‐effectiveness demonstrated here can be repurposed towards engineering other tissues in the future.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202470162