Functional characterization, antimicrobial and antioxidant properties from the biomass extraction of ascidian Phallusia nigra

Novel biologically active molecules have been isolated from the tunic biomass of marine ascidian fauna. In these findings, we evaluated the antimicrobial, antioxidant molecules of methanol and ethanol tissue extracts of tunic ascidians Phallusia nigra . In addition, these experiments along with FT-I...

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Veröffentlicht in:Biomass conversion and biorefinery 2024-07, Vol.14 (13), p.13929-13939
Hauptverfasser: Murugan, Rajaram, Praveena, Varadhan, Ananthan, Gnanakkan
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Sprache:eng
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Zusammenfassung:Novel biologically active molecules have been isolated from the tunic biomass of marine ascidian fauna. In these findings, we evaluated the antimicrobial, antioxidant molecules of methanol and ethanol tissue extracts of tunic ascidians Phallusia nigra . In addition, these experiments along with FT-IR and 1 H NMR analysis allowed us to identify the mainly composed active functional groups. The antimicrobial properties of crude extract of ascidians exhibited a zone of inhibition against all six pathogens. The best antimicrobial activity (29 ± 1.1 mm) was observed by the methanol extract of P. nigra toward Pseudomonas aeruginosa . Besides, the enriched antimicrobial potential was tested in 100 µl concentration of methanol and ethanol against all pathogens. In comparison to methanol extracts, ethanol extracts were more efficient in a higher antioxidant potential of 41.24 ± 2.16%. In the diphenyl picryl hydrazyl (DPPH) system, the strongest radical scavenging activity of 58.62 ± 2.62% was exhibited by the standard ascorbic acid when compared to the tested extracts. FT-IR spectrum indicates the presence of alcohol, phenol, alkanes, and carboxylic acid in functional groups. The 1 H NMR spectrum designates the presence of phenol and amide group of derivatives. The results were found to be responsible for such excellent antimicrobial and antioxidant molecules with unidentified potential compounds. The non-toxic ascidian extractions is an authentic source for pharmacological applications especially utilized for human clinical trials, but much more attention is needed for this unique fauna, particularly on the Indian coast. Graphical abstract
ISSN:2190-6815
2190-6823
DOI:10.1007/s13399-022-03306-2