Glioma type pilocytic astrocytoma "atypical recurrent" and gen BRAF:Clinical case presentation, discussion
The pilocytic astrocytoma (PA), formerly referred to as juvenile pilocytic astrocytomas, are WHO grade I tumors, that commonly occur during childhood and rarely in the adult population. Genetic studies of this tumor report an activation of the MAPK / ERK pathway through changes in the BRAF gene.The...
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Veröffentlicht in: | Acta Neurológica Colombiana 2017-01, Vol.33 (2), p.119 |
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Format: | Artikel |
Sprache: | spa |
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Zusammenfassung: | The pilocytic astrocytoma (PA), formerly referred to as juvenile pilocytic astrocytomas, are WHO grade I tumors, that commonly occur during childhood and rarely in the adult population. Genetic studies of this tumor report an activation of the MAPK / ERK pathway through changes in the BRAF gene.The aim of this article is to report a series of atypical PA cases with an aggressive tumor biology that continue preserving the benign histology or transformed into high-grade gliomas, and review the biology, genetics, and emerging therapeutic possibilities for these cases. And finally expose controversies from the surgical treatment and complementary therapies. |
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ISSN: | 0120-8748 2422-4022 |
DOI: | 10.22379/24224022143 |