Glioma type pilocytic astrocytoma "atypical recurrent" and gen BRAF:Clinical case presentation, discussion

The pilocytic astrocytoma (PA), formerly referred to as juvenile pilocytic astrocytomas, are WHO grade I tumors, that commonly occur during childhood and rarely in the adult population. Genetic studies of this tumor report an activation of the MAPK / ERK pathway through changes in the BRAF gene.The...

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Veröffentlicht in:Acta Neurológica Colombiana 2017-01, Vol.33 (2), p.119
Hauptverfasser: Fernando González Trujillo, Cafiero, Sergio, Olaya, Natalia, Lozano Castillo, Alfonso Javier, Romero Rojas, Alfredo Ernesto, Pedro José Penagos González, Camilo Zubieta Vega, Gil, Nicolás, Gonzalo Melo Gómez
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Zusammenfassung:The pilocytic astrocytoma (PA), formerly referred to as juvenile pilocytic astrocytomas, are WHO grade I tumors, that commonly occur during childhood and rarely in the adult population. Genetic studies of this tumor report an activation of the MAPK / ERK pathway through changes in the BRAF gene.The aim of this article is to report a series of atypical PA cases with an aggressive tumor biology that continue preserving the benign histology or transformed into high-grade gliomas, and review the biology, genetics, and emerging therapeutic possibilities for these cases. And finally expose controversies from the surgical treatment and complementary therapies.
ISSN:0120-8748
2422-4022
DOI:10.22379/24224022143