Thyroid profile in pre-diabetes, is it important?
Background: Individuals with type 2 diabetes mellitus and pre-diabetes have an increased risk of coronary artery disease. Thyroid dysfunction may amplify existing cardiovascular disease risk in hyperglycemic subjects. Studying the association between thyroid profile abnormalities in the pre-diabetes...
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Veröffentlicht in: | National journal of physiology, pharmacy and pharmacology pharmacy and pharmacology, 2024, Vol.14 (7), p.1-1475 |
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creator | Mishra, Soumyaranjan Mohanty, Namita Nahak, Susanta Pati, Sandhyarani Tripathy, Ashutosha |
description | Background: Individuals with type 2 diabetes mellitus and pre-diabetes have an increased risk of coronary artery disease. Thyroid dysfunction may amplify existing cardiovascular disease risk in hyperglycemic subjects. Studying the association between thyroid profile abnormalities in the pre-diabetes population is of considerable clinical importance. Aims and Objectives: The aims and objectives of the study are to study thyroid profile in pre-diabetes and control. Materials and Methods: Group-I: Patients with pre-diabetes are considered cases. (patients with fasting plasma glucose [FPG] – 100–125 mg/dL and/or post-prandial blood glucose 140–199 mg/dL and/or hemoglobin A1c [HbA1c] – 5.7–6.4% as per “American Diabetes Association 2017”). Group-II: Patients with normal FPG, post-prandial blood glucose, and HbA1C are considered controls. Results: Among pre-diabetes, 12% have hypothyroidism as compared to 5% among non-diabetic (P < 0.001). Conclusion: There is a significant increase in the prevalence of hypothyroidism among the prediabetes population. Hence, they should be screened early for these parameters and early management may reduce future cardiovascular morbidity and mortality. |
doi_str_mv | 10.5455/njppp.2024.14.03124202402062024 |
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Thyroid dysfunction may amplify existing cardiovascular disease risk in hyperglycemic subjects. Studying the association between thyroid profile abnormalities in the pre-diabetes population is of considerable clinical importance. Aims and Objectives: The aims and objectives of the study are to study thyroid profile in pre-diabetes and control. Materials and Methods: Group-I: Patients with pre-diabetes are considered cases. (patients with fasting plasma glucose [FPG] – 100–125 mg/dL and/or post-prandial blood glucose 140–199 mg/dL and/or hemoglobin A1c [HbA1c] – 5.7–6.4% as per “American Diabetes Association 2017”). Group-II: Patients with normal FPG, post-prandial blood glucose, and HbA1C are considered controls. Results: Among pre-diabetes, 12% have hypothyroidism as compared to 5% among non-diabetic (P < 0.001). Conclusion: There is a significant increase in the prevalence of hypothyroidism among the prediabetes population. Hence, they should be screened early for these parameters and early management may reduce future cardiovascular morbidity and mortality.</description><identifier>ISSN: 2320-4672</identifier><identifier>EISSN: 2231-3206</identifier><identifier>DOI: 10.5455/njppp.2024.14.03124202402062024</identifier><language>eng</language><publisher>Surat: Association of Physiologists, Pharmacists & Pharmacologists</publisher><subject>Blood pressure ; Cardiovascular disease ; Diabetes ; Endocrinology ; Glucose ; Hemoglobin ; Hyperglycemia ; Hypothyroidism ; Immunoassay ; Morbidity ; Mortality ; Thyroid diseases</subject><ispartof>National journal of physiology, pharmacy and pharmacology, 2024, Vol.14 (7), p.1-1475</ispartof><rights>2024. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). 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Thyroid dysfunction may amplify existing cardiovascular disease risk in hyperglycemic subjects. Studying the association between thyroid profile abnormalities in the pre-diabetes population is of considerable clinical importance. Aims and Objectives: The aims and objectives of the study are to study thyroid profile in pre-diabetes and control. Materials and Methods: Group-I: Patients with pre-diabetes are considered cases. (patients with fasting plasma glucose [FPG] – 100–125 mg/dL and/or post-prandial blood glucose 140–199 mg/dL and/or hemoglobin A1c [HbA1c] – 5.7–6.4% as per “American Diabetes Association 2017”). Group-II: Patients with normal FPG, post-prandial blood glucose, and HbA1C are considered controls. Results: Among pre-diabetes, 12% have hypothyroidism as compared to 5% among non-diabetic (P < 0.001). Conclusion: There is a significant increase in the prevalence of hypothyroidism among the prediabetes population. 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subjects | Blood pressure Cardiovascular disease Diabetes Endocrinology Glucose Hemoglobin Hyperglycemia Hypothyroidism Immunoassay Morbidity Mortality Thyroid diseases |
title | Thyroid profile in pre-diabetes, is it important? |
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