Thyroid profile in pre-diabetes, is it important?

Background: Individuals with type 2 diabetes mellitus and pre-diabetes have an increased risk of coronary artery disease. Thyroid dysfunction may amplify existing cardiovascular disease risk in hyperglycemic subjects. Studying the association between thyroid profile abnormalities in the pre-diabetes population is of considerable clinical importance. Aims and Objectives: The aims and objectives of the study are to study thyroid profile in pre-diabetes and control. Materials and Methods: Group-I: Patients with pre-diabetes are considered cases. (patients with fasting plasma glucose [FPG] – 100–125 mg/dL and/or post-prandial blood glucose 140–199 mg/dL and/or hemoglobin A1c [HbA1c] – 5.7–6.4% as per “American Diabetes Association 2017”). Group-II: Patients with normal FPG, post-prandial blood glucose, and HbA1C are considered controls. Results: Among pre-diabetes, 12% have hypothyroidism as compared to 5% among non-diabetic (P < 0.001). Conclusion: There is a significant increase in the prevalence of hypothyroidism among the prediabetes population. Hence, they should be screened early for these parameters and early management may reduce future cardiovascular morbidity and mortality.