Palladium‐Catalyzed C−H Alkenylation of α‐Aryl Alkyl Nitriles

A direct α‐alkenylation of nitrile compounds was realized with a palladium complex. This method exhibited excellent tolerance toward a variety of α‐aryl alkyl nitriles and vinyl bromides, leading to the formation of a series of α‐quaternary nitriles containing vinyl groups. Further manipulations of the obtained products were demonstrated, highlighting the potential synthetic utility of this method. The direct α‐alkenylation of nitrile was realized with palladium catalyst for the first time. Both cyano group and alkenyl group in the product can be functionalized, rendering this method a powerful protocol to synthesis a series of useful compounds.