Antitumor and Cytotoxic Effect of Silver Polyacrylate

Silver polyacrylate (argacryl) is shown to have antitumor activity in models of solid mouse tumors in vivo and a cytotoxic effect on human tumor cells in vitro. Argacryl enhances the antitumor effect of cisplatin (Lewis lung carcinoma in mice) and does not show cross resistance with cisplatin and do...

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Veröffentlicht in:	Biophysics (Oxford) 2024, Vol.69 (1), p.87-97
Hauptverfasser:	Ostrovskaya, L. A., Korman, D. B., Nekrasova, E. I., Chigasova, A. K., Bluhterova, N. V., Rikova, V. A., Fomina, M. M., Khochenkova, Yu. A., Abzaeva, K. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Antitumor activity Biological and Medical Physics Biophysics Breast carcinoma Cell Biophysics Cell culture Cisplatin Cytotoxicity DNA damage Doxorubicin Lung cancer Lung carcinoma Molecular modelling Physics Physics and Astronomy Polyacrylate Tumor cells
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Zusammenfassung:	Silver polyacrylate (argacryl) is shown to have antitumor activity in models of solid mouse tumors in vivo and a cytotoxic effect on human tumor cells in vitro. Argacryl enhances the antitumor effect of cisplatin (Lewis lung carcinoma in mice) and does not show cross resistance with cisplatin and doxorubicin (human breast cancer MCF-7). The molecular mechanism of action of argacryl could be associated with the induction of single-strand DNA breaks in the absence of crosslinking in the DNA molecule.
ISSN:	0006-3509 1555-6654
DOI:	10.1134/S0006350924700106