Ribosomes moonlight as enzyme activators

Loveland and colleagues conclude that ANG occupies a region of the ribosome called the A-site, which is where the ribosome accepts the incoming amino-acid-bound tRNA (Fig. 1). [...]the anticodon loop of these tRNAs is presented to the active site of ANG. [...]the ribosome has a central role both in activating ANG and in determining its substrate specificity. [...]it will be important to examine the role of ribosome-ANG-tRNA functional interactions in relation to human disease.