Ponatinib-Related Vasospastic Angina

Tyrosine kinase inhibitors (TKIs) are essential drugs for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Cardiovascular or arteriothrombotic adverse events have been reported in patients treated with TKIs. We report 3 cases of Ponatinib-related vasospasti...

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Veröffentlicht in:	International Heart Journal 2024/03/30, Vol.65(2), pp.349-353
Hauptverfasser:	Shindo, Michiho, Komiyama, Chinatsu, Yamaguchi, Tetsuo, Kageyama, Kosei, Yamamoto, Hisashi, Fujimoto, Yo, Uchida, Naoyuki, Kodama, Takahide
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Angina Calcium nitrate Cardio-oncology Chronic myeloid leukemia Lymphatic leukemia Myeloid leukemia Onco-cardiology Philadelphia chromosome Tyrosine kinase inhibitor Tyrosine kinase inhibitors Vasospasm
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Beschreibung
Zusammenfassung:	Tyrosine kinase inhibitors (TKIs) are essential drugs for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Cardiovascular or arteriothrombotic adverse events have been reported in patients treated with TKIs. We report 3 cases of Ponatinib-related vasospastic angina, in which prophylactic administration of nitrates or calcium channel blockers was effective.
ISSN:	1349-2365 1349-3299
DOI:	10.1536/ihj.23-355