Application of Biaryl Phosphacycles in Palladium‐Catalysed Suzuki‐Miyaura Cross‐Coupling Reactions of Aryl Chlorides

The use of Pd‐catalysts based on biaryl phosphacycles allowed facile Suzuki‐Miyaura couplings of a wide range of deactivated, sterically hindered, and heteroaryl chloride substrates with aryl boronic acids. Notably, the strongly electron‐deficient and sufficiently hindered biaryl phosphacycle ligand 7 consistently demonstrated effective performance. Structure‐activity studies of biaryl phosphacyclic and dialkyl ligands revealed fine‐tuned steric bulk to be crucial for efficient coupling of structurally and electronically diverse aryl chlorides and arylboronic acids.