Prenylated Flavonoids from Desmodium caudatum and as Potential Activators for SARS-CoV-2

Prenylated Flavonoids from Desmodium caudatum and as Potential Activators for SARS-CoV-2

Two new isoprenylated flavone, 8,4′-dimethoxy-6-(4-methyl-1H-pyrrol-2-yl)-flavone ( 1 ), 8-hydroxy-4′-methoxy-6-(4-methyl-1H-pyrrol-2-yl)-flavone ( 2 ), together with seven known isoprenylated flavonoids ( 3–9 ) were isolated from the whole plants of Desmodium caudatum . Their structures were establ...

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Veröffentlicht in:Chemistry of natural compounds 2024, Vol.60 (3), p.423-427
Hauptverfasser: Zhao, Gui-Juan, Yang, Min, Zhang, Yan-Qun, Li, Gui-Feng, Pu, Gui, Yao, Sui, Miao, Dong, Li, Yin-Ke, Hu, Qiu-fen, Yang, Xin-Zhou
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Flavonoids
NMR
Nuclear magnetic resonance
Organic Chemistry
Plant Sciences
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Zusammenfassung:Two new isoprenylated flavone, 8,4′-dimethoxy-6-(4-methyl-1H-pyrrol-2-yl)-flavone ( 1 ), 8-hydroxy-4′-methoxy-6-(4-methyl-1H-pyrrol-2-yl)-flavone ( 2 ), together with seven known isoprenylated flavonoids ( 3–9 ) were isolated from the whole plants of Desmodium caudatum . Their structures were established by their 1D, 2D NMR, and MS spectral data. In addition, compounds 1–9 were tested for their anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) activity.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-024-04342-2