A Percutaneous Delivery System for a Nicotinamide Transdermal Therapeutic System
—A percutaneous delivery system for nicotinamide is developed and its functional properties are studied in vitro. Four compositions of the emulsion percutaneous delivery system for a nicotinamide transdermal therapeutic system (TTS) are suggested, in which the amount of the percutaneous carrier, doc...
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| Veröffentlicht in: | Inorganic materials : applied research 2024-04, Vol.15 (2), p.336-343 |
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| creator | Kuznetsova, E. G. Ryzhikova, V. A. Salomatina, L. A. Kuryleva, O. M. Sevastianov, V. I. |
| description | —A percutaneous delivery system for nicotinamide is developed and its functional properties are studied in vitro. Four compositions of the emulsion percutaneous delivery system for a nicotinamide transdermal therapeutic system (TTS) are suggested, in which the amount of the percutaneous carrier, docusate sodium, is varied. The performed studies of the diffusion of nicotinamide in vitro through unpreserved rabbit skin show that increasing the concentration of docusate sodium threefold (from 3.3 up to 9.8%) significantly increases the amount of the diffused drug substance by ~15% and decreases its residual concentration in the TTS. The amount of the antioxidant detected in the skin flap is lower than the therapeutic dose (~1.46% of its initial amount in the TTS) within 24 h after the start of the in vitro experiment, which indicates the absence of a possible aftereffect of the nicotinamide TTS in its clinical use after detaching from the patient’s skin. |
| doi_str_mv | 10.1134/S2075113324020291 |
| format | Article |
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G. ; Ryzhikova, V. A. ; Salomatina, L. A. ; Kuryleva, O. M. ; Sevastianov, V. I.</creator><creatorcontrib>Kuznetsova, E. G. ; Ryzhikova, V. A. ; Salomatina, L. A. ; Kuryleva, O. M. ; Sevastianov, V. I.</creatorcontrib><description>—A percutaneous delivery system for nicotinamide is developed and its functional properties are studied in vitro. Four compositions of the emulsion percutaneous delivery system for a nicotinamide transdermal therapeutic system (TTS) are suggested, in which the amount of the percutaneous carrier, docusate sodium, is varied. The performed studies of the diffusion of nicotinamide in vitro through unpreserved rabbit skin show that increasing the concentration of docusate sodium threefold (from 3.3 up to 9.8%) significantly increases the amount of the diffused drug substance by ~15% and decreases its residual concentration in the TTS. The amount of the antioxidant detected in the skin flap is lower than the therapeutic dose (~1.46% of its initial amount in the TTS) within 24 h after the start of the in vitro experiment, which indicates the absence of a possible aftereffect of the nicotinamide TTS in its clinical use after detaching from the patient’s skin.</description><identifier>ISSN: 2075-1133</identifier><identifier>EISSN: 2075-115X</identifier><identifier>DOI: 10.1134/S2075113324020291</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Chemistry ; Chemistry and Materials Science ; Industrial Chemistry/Chemical Engineering ; Inorganic Chemistry ; Materials for Human Life Support and Environmental Protection ; Materials Science ; Nicotinamide ; Pharmaceuticals ; Sodium</subject><ispartof>Inorganic materials : applied research, 2024-04, Vol.15 (2), p.336-343</ispartof><rights>Pleiades Publishing, Ltd. 2024. ISSN 2075-1133, Inorganic Materials: Applied Research, 2024, Vol. 15, No. 2, pp. 336–343. © Pleiades Publishing, Ltd., 2024. Russian Text © The Author(s), 2023, published in Perspektivnye Materialy, 2023, No. 7, pp. 46–56.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c198t-74abe27bcf9e80d668fa80b8f12b0d3e6d993dddc5286bb5358b722c44def2ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S2075113324020291$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S2075113324020291$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Kuznetsova, E. G.</creatorcontrib><creatorcontrib>Ryzhikova, V. 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The performed studies of the diffusion of nicotinamide in vitro through unpreserved rabbit skin show that increasing the concentration of docusate sodium threefold (from 3.3 up to 9.8%) significantly increases the amount of the diffused drug substance by ~15% and decreases its residual concentration in the TTS. The amount of the antioxidant detected in the skin flap is lower than the therapeutic dose (~1.46% of its initial amount in the TTS) within 24 h after the start of the in vitro experiment, which indicates the absence of a possible aftereffect of the nicotinamide TTS in its clinical use after detaching from the patient’s skin.</description><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Inorganic Chemistry</subject><subject>Materials for Human Life Support and Environmental Protection</subject><subject>Materials Science</subject><subject>Nicotinamide</subject><subject>Pharmaceuticals</subject><subject>Sodium</subject><issn>2075-1133</issn><issn>2075-115X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLw0AUhQdRsNT-AHcDrqPzyCQzy1KfULTQCu7CPO5oSh51JhH6701J0YV4N_dwOd-5cBC6pOSaUp7erBnJxaA4SwkjTNETNDmcEkrF2-mP5vwczWLckmEEFSoVE7Sa4xUE23e6gbaP-Baq8gvCHq_3sYMa-zZgjZ9L23Zlo-vSAd4E3UQHodYV3nxA0Dvou9IeiQt05nUVYXbcU_R6f7dZPCbLl4enxXyZWKpkl-SpNsByY70CSVyWSa8lMdJTZojjkDmluHPOCiYzYwQX0uSM2TR14JnRfIquxtxdaD97iF2xbfvQDC8LTjKSK5ITNrjo6LKhjTGAL3ahrHXYF5QUh-6KP90NDBuZOHibdwi_yf9D32VocK8</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Kuznetsova, E. 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Four compositions of the emulsion percutaneous delivery system for a nicotinamide transdermal therapeutic system (TTS) are suggested, in which the amount of the percutaneous carrier, docusate sodium, is varied. The performed studies of the diffusion of nicotinamide in vitro through unpreserved rabbit skin show that increasing the concentration of docusate sodium threefold (from 3.3 up to 9.8%) significantly increases the amount of the diffused drug substance by ~15% and decreases its residual concentration in the TTS. The amount of the antioxidant detected in the skin flap is lower than the therapeutic dose (~1.46% of its initial amount in the TTS) within 24 h after the start of the in vitro experiment, which indicates the absence of a possible aftereffect of the nicotinamide TTS in its clinical use after detaching from the patient’s skin.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S2075113324020291</doi><tpages>8</tpages></addata></record> |
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| subjects | Chemistry Chemistry and Materials Science Industrial Chemistry/Chemical Engineering Inorganic Chemistry Materials for Human Life Support and Environmental Protection Materials Science Nicotinamide Pharmaceuticals Sodium |
| title | A Percutaneous Delivery System for a Nicotinamide Transdermal Therapeutic System |
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